Preventing Sedentary Lifestyles among Children Born with Congenital Heart Defects; A feasibility study of physical activity after surgical or catheterization intervention

PI: Pat Longmuir Study Contact: [email protected] Study Contact Full Name: Jenna Yaraskavitch Lay Summary: Active play is critically important for young children. It is essential for normal growth and development and is how children socialize with peers. Our previous study among 127 children with a congenital heart defects found lower activity levels among patients 18 … Read more

Needs assessment for gender related healthcare transition from pediatric to adult care for transgender and nonbinary youth

PI: Dr. Karine Khatchadourian Study contact: [email protected] Study contact full name: Elias Abou-Assaly Research Area: Gender Diversity Who to contact regarding participating: Dr. Gabrielle Doré-Brabant ([email protected]) Lay Summary: This study aims to explore the perspectives of Transgender and nonbinary youth and their caregiver(s), both pre- and post-transition, to identify needs and concerns regarding transition of … Read more

LOGGIC/FIREFLY-2: A Phase 3, Randomized, International Multicenter Trial Of DAY101 Monotherapy Versus Standard Of Care Chemotherapy In Patients With Pediatric Low-Grade Glioma Harboring An Activating RAF Alteration Requiring First-Line Systemic Therapy

PI: Dr. Nirav Thacker Study contact: [email protected] Study contact full name: Isabelle Laforest Research Area: Cancer Who to contact regarding participating: Isabelle Laforest Lay Summary: This is a 2-arm, randomized, open-label, multicenter, global, Phase 3 study to evaluate the efficacy, safety, and tolerability of tovorafenib monotherapy versus SoC chemotherapy in patients with pediatric low-grade glioma … Read more

PROTOCOL-1: Pneumococcal vaccine research trial

PI: Dr. Charles Hui Study contact: [email protected] Study contact full name: Jennifer Bowes Research area: Vaccination Who to contact regarding participation: [email protected] Lay summary: PROTOCOL-1 is a pneumococcal vaccine research trial for children and adolescents with chronic disease (or chronic medical conditions) Pneumococcal disease is an illness caused by certain germs (bacteria) called Streptococcus pneumoniae. These germs can cause serious infections … Read more

The PROMOTE Trial: PRecisiOn Microbiome Directed ExtensiOn of Anti-TNFα Crohn’s Disease ThErapy in Children

PI: Dr. David Mack Study contact: [email protected] Study contact full name: Ruth Singleton Research Area: Inflammatory Bowel Disease (IBD) (Gastrointestinal Conditions) Who to contact regarding participating: [email protected] Lay Summary: The PROMOTE study is being done to find out whether better gut (intestinal microbiome) health will reduce the need for greater amounts of your anti-TNFα medications … Read more

Evaluating a self-directed, web-based training for an ADHD strength-based diagnostic interview

Man sitting at computer doing a video training session.

PI: Philippe Robaey Study contact: [email protected] Study contact full name: Benjamin Hudson Research Area: Mental Health Who to contact regarding participating: Benjamin Hudson Lay Summary: ADHD is a complex condition with a high number of diagnostic criteria, overlapping symptoms, and often accompanies other disorders. Despite this, ADHD is commonly diagnosed in short assessments that generalize … Read more

HELP (HEalthy Lifestyles Project) for Youth with Mental Distress E-Health Intervention: Patient and Healthcare Impacts

PI: Dr. Pat Longmuir and Clare Gray Study contact: [email protected] Study contact full name: Pat Longmuir Research Area: Mental Health Who to contact regarding participating: Eesha Mehra at [email protected] Lay Summary:  In Ontario, youth mental health is in crisis: suicide/self-harm doubled 2019-2022; 75% of youth with mental illness do not get care; 28,000 youth wait 8-12 … Read more

Neuromelanin-sensitive MRI as a Biomarker of the Response to Methylphenidate in children with ADHD

Little girl lying on table of mri scan equipment while gloved assistant pressing start button on panel

PI: Philippe Robaey Study contact: [email protected] Study contact full name: Chantale Melo Research Area: Attention Deficit Hyperactivity Disorder (ADHD) Who to contact regarding participating: Anisa Soucy, Project Coordinator: [email protected] Lay Summary: We will test whether a brain imaging method (Neuromelanin-Magnetic Resonance Imaging) can predict the response to the stimulant in children with ADHD, and define … Read more