LOGGIC/FIREFLY-2: A Phase 3, Randomized, International Multicenter Trial Of DAY101 Monotherapy Versus Standard Of Care Chemotherapy In Patients With Pediatric Low-Grade Glioma Harboring An Activating RAF Alteration Requiring First-Line Systemic Therapy

PI: Dr. Nirav Thacker Study contact: [email protected] Study contact full name: Isabelle Laforest Research Area: Cancer Who to contact regarding participating: Isabelle Laforest Lay Summary: This is a 2-arm, randomized, open-label, multicenter, global, Phase 3 study to evaluate the efficacy, safety, and tolerability of tovorafenib monotherapy versus SoC chemotherapy in patients with pediatric low-grade glioma … Read more

MOvement behaviours and health indicators in children with a chronic MEdical condition or disability: an iNTernational mUlti-centre prograM (MOMENTUM): A pilot study to test a novel health survey

PI: Pat Longmuir Study contact: [email protected] Study contact full name: Pat Longmuir Research Area: Healthy Active Living and Obesity Who to contact regarding participating: Jenna Yaraskavitch Lay Summary: Momentum is a survey project designed to gather information about healthy lifestyles (physical activity, nutrition, sleep, screen time, emotional well-being) among adolescents (12-17 years of age) with … Read more

PROTOCOL-1: Pneumococcal vaccine research trial

PI: Dr. Charles Hui Study contact: [email protected] Study contact full name: Jennifer Bowes Research area: Vaccination Who to contact regarding participation: [email protected] Lay summary: PROTOCOL-1 is a pneumococcal vaccine research trial for children and adolescents with chronic disease (or chronic medical conditions) Pneumococcal disease is an illness caused by certain germs (bacteria) called Streptococcus pneumoniae. These germs can cause serious infections … Read more

The PROMOTE Trial: PRecisiOn Microbiome Directed ExtensiOn of Anti-TNFα Crohn’s Disease ThErapy in Children

PI: Dr. David Mack Study contact: [email protected] Study contact full name: Ruth Singleton Research Area: Inflammatory Bowel Disease (IBD) (Gastrointestinal Conditions) Who to contact regarding participating: [email protected] Lay Summary: The PROMOTE study is being done to find out whether better gut (intestinal microbiome) health will reduce the need for greater amounts of your anti-TNFα medications … Read more

Evaluating a self-directed, web-based training for an ADHD strength-based diagnostic interview

Man sitting at computer doing a video training session.

PI: Philippe Robaey Study contact: [email protected] Study contact full name: Benjamin Hudson Research Area: Mental Health Who to contact regarding participating: Benjamin Hudson Lay Summary: ADHD is a complex condition with a high number of diagnostic criteria, overlapping symptoms, and often accompanies other disorders. Despite this, ADHD is commonly diagnosed in short assessments that generalize … Read more

HELP (HEalthy Lifestyles Project) for Youth with Mental Distress E-Health Intervention: Patient and Healthcare Impacts

PI: Dr. Pat Longmuir and Clare Gray Study contact: [email protected] Study contact full name: Pat Longmuir Research Area: Mental Health Who to contact regarding participating: Jenna Yaraskavitch at [email protected] Lay Summary: In Ontario, youth mental health is in crisis: suicide/self-harm doubled 2019-2022; 75% of youth with mental illness do not get care; 28,000 youth wait 8-12 … Read more

Neuromelanin-sensitive MRI as a Biomarker of the Response to Methylphenidate in children with ADHD

Little girl lying on table of mri scan equipment while gloved assistant pressing start button on panel

PI: Philippe Robaey Study contact: [email protected] Study contact full name: Chantale Melo Research Area: Attention Deficit Hyperactivity Disorder (ADHD) Who to contact regarding participating: Anisa Soucy, Project Coordinator: [email protected] Lay Summary: We will test whether a brain imaging method (Neuromelanin-Magnetic Resonance Imaging) can predict the response to the stimulant in children with ADHD, and define … Read more

Clinical, Imaging, and Endoscopic Outcomes of Children Newly Diagnosed with Crohn’s Disease (CAMEO)

Hand holding intestine shape.

PI: Dr. David Mack Study contact: [email protected] Study contact full name: Ruth Singleton Area of Research: Inflammatory Bowel Disease (IBD) (Gastrointestinal conditions) Who to contact regarding participating: Ruth Singleton Lay Summary: The CAMEO research study is about outcomes of patients newly diagnosed with Crohn’s disease (CD). Crohn’s disease is a condition that causes inflammation of … Read more