Arthritis and Rheumatology

The pediatric rheumatology research team is focusing on the following areas of research:

  • Muscle function and muscle function deficits in rheumatic diseases
  • Ultrasound of the musculoskeletal system in children
  • Longitudinal studies on short and long-term outcomes in JIA
  • Psycho Social Outcomes in rheumatic diseases
  • Therapeutic trials of new medication
  • The links between exercise, physical activity and pathophysiology in JIA (LEAP study)
  • The overarching goal is to provide best possible treatment that has been properly evaluated, improve the diagnostic possibilities and ensure optimal outcomes in all relevant areas (physical and psychosocial) through research

Research Projects

  1. Mitigating the Denosumab‑Induced Rebound Phenomenon with Alternating Short‑ and Long‑Acting Anti‑resorptive Therapy in a Young Boy with Severe OI Type V

    03/03/2023

  2. Toward Developing a Semiquantitative Whole Body-MRI Scoring for Juvenile Idiopathic Arthritis: Critical Appraisal of the State of the Art, Challenges, and Opportunities.

    02/03/2020

  3. SMAC mimetics and RIPK inhibitors as therapeutics for chronic inflammatory diseases

    18/02/2020

    This may benefit and guide the development of SMs or selective RIPK inhibitors as anti-inflammatory therapeutics for various chronic inflammatory conditions.

  4. Prospective Determination of the Incidence and Risk Factors of New-Onset Uveitis in Juvenile Idiopathic Arthritis: The Research in Arthritis in Canadian Children Emphasizing Outcomes Cohort

    01/11/2019

    Identification of the incidence of juvenile idiopathic arthritis (JIA)-associated uveitis and its risk factors is essential to optimize early detection. Data from the Research in Arthritis in Canadian Children Emphasizing Outcomes inception cohort were used to estimate the annual incidence of new-onset uveitis following JIA diagnosis and to identify associated risk factors.

  5. Understanding parent perceptions of healthy physical activity for their child with a chronic medical condition: A cross-sectional study

    01/06/2019

    Over one-third of parents reported having questions about physical activity for their child with a chronic medical condition, suggesting substantial uncertainty even among children reported as active. Presence of parent uncertainty is associated with parent reports of the child being unwell or a history of cardiac arrhythmia

  6. Health-Related Quality of Life in an InceptionCohort of Children With Juvenile IdiopathicArthritis: A Longitudinal Analysis

    02/01/2018

    Improvement in HRQoL is slower than for disease activity, pain, and disability. Improvement of a mea- sure based on respondents’ preferences (HRQoML) is more rapid than that of a standardized measure (JAQQ). Higher disease activity at diagnosis heralds an unfavorable HRQoL trajectory.

  7. The risk and nature of flares in juvenile idiopathic arthritis: results from the ReACCh-Out cohort

    01/05/2015

    In this real-practice JIA cohort, flares were frequent, usually involved a few swollen joints for an average of 6 months and 60% led to treatment intensification. Children with a severe disease course had an increased risk of flare.

Researchers

  1. Sasha Carsen

    Scientist, CHEO Research Institute

    View Profile Email

  2. Ciarán Duffy

    Emeritus Scientist, CHEO Research Institute

    View Profile Email

  3. Dina El Demellawy

    Investigator, CHEO Research Institute

    View Profile Email

  4. Kerri Highmore

    Investigator, CHEO Research Institute

    View Profile Email

  5. Eric LaCasse

    Associate Scientist, CHEO Research Institute

    View Profile Email

  6. Patricia Longmuir

    Senior Scientist, CHEO Research Institute

    View Profile Email

  7. Marie-Eve Robinson

    Investigator, CHEO Research Institute

    View Profile Email

  8. Kevin Smit

    Investigator, CHEO Research Institute

    View Profile Email

  9. Leanne Ward

    Senior Scientist, CHEO Research Institute

    View Profile Email