The team’s vision is to conduct and disseminate high-quality clinical research in infectious diseases of children and youth in collaboration with local, provincial and national partners. The research focuses on the prevention, diagnosis, management and impact of infectious diseases in children and youth with specific attention to vulnerable populations.
Themes:
- Vaccination/immunizations
- Primary and acquired immune deficiencies/HIV
- Molecular diagnostics
- Health care associated infections
- New Canadians (immigrants, refugees, internationally adopted)
- Evidence-based health advocacy
Related News
Research Projects
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Near real-time determination of B. 1.1. 7 in proportion to total SARS-CoV-2 viral load in wastewater using an allele-specific primer extension PCR strategy
15/10/2021
Our study demonstrates that this strategy can provide public health units with an additional and much needed tool to rapidly triangulate VOC incidence/prevalence with high sensitivity and lineage specificity.
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The role of wastewater testing for SARS-CoV-2 surveillance
26/08/2021
These characteristics of SARS-CoV-2 infection, along with the observation that SARSCoV-2 is excreted in stools during all phases of infection, has led to the uptake of wastewater testing to complement SARS-CoV-2 surveillance based on clinical tests and case identification.
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Quantitative analysis of SARS-CoV-2 RNA from wastewater solids in communities with low COVID-19 incidence and prevalence
19/08/2020
Can we find COVID-19 markers in the wastewater that will help predict outbreaks?
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Combined influence of practice guidelines and prospective audit and feedback stewardship on antimicrobial treatment of community-acquired pneumonia and empyema in children: 2012 to 2016
30/06/2020
Use of AAP should also be strongly considered in patients with effusions (even if no pathogen is identified), as clinical outcome appears similar to patients treated with broad-spectrum antimicrobials.
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CpG Methylation in TGFβ1 and IL-6 Genes as Surrogate Biomarkers for Diagnosis of IBD in Children
14/05/2020
We found that CpG methylation in the promoter of the TGFβ1 gene has high discriminative power for identifying CD and UC and could serve as an important diagnostic marker
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Epidemiology and Clinical Outcomes of Hospitalizations for Acute Respiratory or Febrile Illness and Laboratory-Confirmed Influenza Among Pregnant Women During Six Influenza Seasons, 2010–2016
01/05/2020
Our findings characterize seasonal influenza hospitalizations among pregnant women and can inform assessments of the public health and economic impact of seasonal influenza on pregnant women.
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SMAC mimetics and RIPK inhibitors as therapeutics for chronic inflammatory diseases
18/02/2020
This may benefit and guide the development of SMs or selective RIPK inhibitors as anti-inflammatory therapeutics for various chronic inflammatory conditions.
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Health outcomes of young children born to mothers who received 2009 pandemic H1N1 influenza vaccination during pregnancy: retrospective cohort study
01/07/2019
Pregnant women are considered to be at high risk for serious illness due to influenza related mortality and morbidity documented during influenza pandemics and seasonal epidemics. No associations were observed between exposure to pH1N1 influenza vaccine during pregnancy and most five year pediatric health outcomes.
Researchers
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Tommy Michel Alain
Senior Scientist, CHEO Research Institute
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Jason Brophy
Investigator, CHEO Research Institute
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Melanie Buba
Investigator, CHEO Research Institute
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Deshayne Fell
Affiliate Investigator, CHEO Research Institute
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Tyson Graber
Associate Scientist
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Eric LaCasse
Associate Scientist, CHEO Research Institute
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Alex MacKenzie
Senior Scientist, CHEO Research Institute
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David Mack
Senior Scientist, CHEO Research Institute
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Dayre McNally
Senior Scientist, CHEO Research Institute
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Anne Pham-Huy
Investigator, CHEO Research Institute
